San Miguel is a one-horse town being pulled apart by two rival families who seek to control its strategic position on the Mexican border. Enter The Man With No Name (Clint Eastwood) — a laconic gunslinger for hire who drifts into town and spots an opportunity.

Clint Eastwood returns as the The Man With No Name, who teams up with equally lethal Colonel Douglas Mortimer (Lee Van Cleef) in pursuit of a sadistic killer and his band of desperadoes.

Joined by mercenary drifter Angel Eyes, The Man With No Name and Tuco team up and cross the desert to find buried Confederate treasure.